Synthetic k2 spice are a class of molecules that bind to the same receptors to which cannabinoids (THC and CBD) in cannabis plants attach. K2 incense are designer drugs. Consumers commonly spray k2 onto plant matter and usually smoke k2. However, since 2016 some consumers in US and UK ingest spice as a concentrated liquid. Marketers sell spice as herbal incense, or “herbal smoking blends”. K2, Spice, and Synthetic Marijuana are common names. They are often labeled “not for human consumption” for liability defence. Most synthetic herbal incense are agonists of the cannabinoid receptors. They are similar to THC, the natural cannabinoid with the strongest binding affinity to the CB1 receptor. THC gives the psychoactive effects or “high” of marijuana. These synthetic analogs often have greater binding affinity and greater potency to the CB1 receptors.

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